The Effects of COMT (Val108/158Met) and DRD4 (SNP 2521) Dopamine Genotypes on Brain Activations Related to Valence and Magnitude of Rewards
نویسندگان
چکیده
Department of Psicologia Basica, Faculty of Psychology, University of Barcelona, 08035 Barcelona, Spain, Department of Neuropsychology, Otto von Guericke University, 39106 Magdeburg, Germany, Department of Neurology, Medical School Hannover, 30623 Hannover, Germany, Department of Medical Genetics, University of Tübingen, 72074 Tübingen, Germany, Department of Clinical Neurogenetics, Hertie-Institut für KlinischeHirnforschung, University of Tübingen, 72074 Tübingen, Germany, Department of Neurology, Otto von Guericke University, 39106 Magdeburg, Germany, Institució Catalana de Recerca i Estudis Avanc xats (ICREA), 08010 Barcelona, Spain and Center for Behavioral Brain Science, 39106 Magdeburg, Germany
منابع مشابه
The effects of COMT (Val108/158Met) and DRD4 (SNP -521) dopamine genotypes on brain activations related to valence and magnitude of rewards.
People's sensitivity to reinforcing stimuli such as monetary gains and losses shows a wide interindividual variation that might in part be determined by genetic differences. Because of the established role of the dopaminergic system in the neural encoding of rewards and negative events, we investigated young healthy volunteers being homozygous for either the Valine or Methionine variant of the ...
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The functional catechol-O-methyltransferase (COMT Val108/158Met) polymorphism has been shown to have an impact on tasks of executive function, memory and attention and recently, tasks with an affective component. As oestrogen reduces COMT activity, we focused on the interaction between gender and COMT genotype on brain activations during an affective processing task. We used functional MRI (fMR...
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Preliminary evidence suggests that a single nucleotide polymorphism (SNP), the val108/158met SNP, within the gene that codes for catechol-O-methyltransferase (COMT), a key enzyme involved in regulating dopamine (DA) transmission within the prefrontal cortex (PFC), is related to cognitive function in schizophrenia and cognitive improvement with atypical antipsychotic drugs (APDs). Specifically, ...
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Humans are faced with the dilemma to maintain a stable cognitive set on the one hand and to be able to redirect and switch attention to novel stimuli of potential importance. The dopaminergic system has been implicated in the balance between these two antagonistic constraints and in particular in novelty processing. Here we studied the impact of two polymorphisms affecting dopaminergic function...
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BACKGROUND Executive control of attention in schizophrenia has recently been assessed by means of the Attention Network Test (ANT). In the past, for tasks assessing executive attention, findings in schizophrenia have been contradictory, among others suggesting a lack of increased stimulus interference effects. Attention and executive functioning are substantially influenced by candidate genes o...
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تاریخ انتشار 2009